Tumor Cell Heterogeneity Origins and Implications. the Bristol-Myers Cancer Symposia, Volume Four. (Bristol-Myers cancer symposia) by Albert H. Owens

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Number of Pages534
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ISBN 100125315201
ISBN 109780125315203

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Tumor progression and exposure to therapeutic agents lead to further molecular evolution and heterogeneity that is clinically relevant.

Moreover, tumors that evolve after diagnosis and as a function of therapy generally become more aggressive and refractory to available therapeutics, including targeted agents and by: 2.

Cell Heterogeneity. Tumor cell heterogeneity is a chief contributor to tumor invasion, metastasis, and resistance to drug therapy [52,88]. From: Principles of Regenerative Medicine.

Cancer evolution and resistance to treatment is caused by tumor heterogeneity, therefore a greater comprehension of the underlining dynamics. J.W.

Cassidy, A. Bruna, in Patient Derived Tumor Xenograft Models, Evolution of the Cancer Stem Cell Model. In summary, tumor heterogeneity is undoubtedly due, at least in part, to the stability of multiple genomic clonal populations within a neoplasm.

18 These arise from divergent evolution of the originating cells’ progeny and may be sustained by geographical isolation within the. This heterogeneity might result in a non-uniform distribution of genetically distinct tumour-cell subpopulations across and within disease sites (spatial heterogeneity) or temporal variations in Cited by:   This heterogeneity was also found in established tumor cell lines.

Cells from an established cell line would be injected into a nude mouse. The resulting tumor was then excised and homogenized, split into 3 parts and set up against a panel of drugs. Once again 3 different results. That tumor heterogeneity itself is an area suitable for experimental and clinical investigation has not been widely appreciated.

The purpose of this chapter is to review the experimental and clinical basis for intra-tumor heterogeneity and to speculate on its possible significance to cancer therapeutics.

Single‐cell analysis of CTCs is a challenge because each individual cell carries picogram (pg) quantities of RNA and DNA, requiring highly sensitive analytical methods. CTCs in a cancer patient's blood derive from different tumor cell subpopulations, as well as from different metastatic : Evelyn K.

Sigal, Stefanie S. Jeffrey. Heterogeneity in the microenvironment of a cancer can be described as a non-cell autonomous driver of cancer cell diversity 62; in a highly diverse microenvironment, different cellular phenotypes may be selected for or against in different regions of the tumour.

For example, any sizeable tumour will inevitably contain areas of hypoxia and by: Although tumor heterogeneity is widely accepted, the existence of cancer stem cells (CSCs) and their proposed role in tumor maintenance has always been challenged and remains a matter of debate.

Many heterogenous non-tumorigenic cell populations in the stroma surrounding tumor mass like fibroblasts, ECM, immune cells, and otherswhose function is pirated by cancer cells also contribute toward carcinogenesis and behave as members of the tumor mass increasing heterogeneity.(6) Some cancers often follow a strategy in which non-tumorigenic.

This review will discuss the vast spatial and functional heterogeneity in the tumor-infiltrating immune system, with particular focus on natural killer (NK) cells, as well as the impact of tumor cell-specific factors, such as secretome composition, receptor–ligand repertoire, and neoantigen diversity, which can further drive immunological Cited by: 2.

Tumor heterogeneity represents an ongoing challenge in the field of cancer therapy. Heterogeneity is evident between cancers from different patients (inter-tumor heterogeneity) and within a single tumor (intra-tumor heterogeneity).

The latter includes phenotypic diversity such as cell surface markers, (epi)genetic abnormality, growth rate, apoptosis and other hallmarks of cancer that Cited by: The clinical and molecular heterogeneity of various cancer types is well documented.

In the era of precision oncology whereby molecular profiling of tumors is incorporated into clinical care, both intra- and intertumoral molecular and genetic heterogeneity have been described. Together, they impact patient treatment and outcomes. Host genetics and the tumor microenvironment impact on tumor Cited by: 2.

Conversely, intratumor heterogeneity refers to the presence of different cell subpopulations within a given tumor sample. These subpopulations, which are often referred to as tumor clones, may differ in cell morphology, genetic makeup, metabolism, proliferation rate, and metastatic potential.

2,3,5 Indeed, intratumor heterogeneity exists at several by: Round 1. Reviewer 1 Report. Lim et a review on single-cell analysis of circulating tumor cells (CTCs) and why heterogeneity authors reviewed nicely recent single-cell CTC sequencing efforts, and the integrated workflows, that have successfully characterized patient-derived CTCs.

Tumor heterogeneity in the clinic. The clonal evolution of tumor cell populations. Science23–28 (). Amir, E. et al. Prospective study ev aluating the impact of tissue. Tumor heterogeneity represents a major hurdle for therapy, which may only target a subset of tumor cells.

In addition, cancer cell plasticity permits rapidly adaption to therapeutics and development of tolerance and resistance, presenting additional challenges for both targeted and immunotherapies.

Additional Physical Format: Online version: Leith, John T. Mammalian tumor cell heterogeneity. Boca Raton, Fla.: CRC Press, © (OCoLC)   Phenotypic and functional heterogeneity arise among cancer cells within the same tumour as a consequence of genetic change, environmental differences and reversible changes in cell properties.

single tumor can complicate this approach. While collaborative molecular profiling efforts like The Cancer Genome Atlasi have enhanced our understanding of intertumoral heterogeneity across patients, efforts to dissect intratumoral heterogeneity are at a much earlier stage.

Nonetheless, this information is likely to be crucial to the rational. COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

Tumor evolution and compositional heterogeneity. A, Evolution drives heritable heterogeneity and subsequent outgrowth of malignant ion pressures from the local microenvironment (e.g. hypoxia, secretion of growth-inhibiting factors, chemotherapeutic agents, etc.) challenge tumor cell survival, often resulting in cell death in early cancer by: from the Book Microbiome and Cancer.

Sarcoma Stem Cell Heterogeneity. from the Book Stem Cells Heterogeneity - Novel Concepts. Autophagy and Tumorigenesis in Drosophila.

from the Book The Drosophila Model in Cancer. Profiling Tumor Infiltrating Immune Cells with CIBERSORT. from the Book Cancer Systems Biology - Methods and Protocols. Tumor heterogeneity has been suggested based on clinical and pathological findings. Several clinical findings can be explained by tumor evolution during progression and metastasis.

We herein report a case of metastatic breast cancer indicated tumor heterogeneity by clinical findings and a genomic analysis.

A year-old woman with advanced breast cancer was treated with primary Cited by: 3. Typical tumor vessels are tortuous, leaky, and discontinuous, and they are invested with disorganized peri-endothelial supportive cells.

The determinant of tumor vasculature heterogeneity is dictated in part by dys regulated expression of tumor-derived angiogenic factors, including VEGFs, FGFs, PDGFs, as well as yet unrecognized angiogenic by: The sampling of tumor cells that circulate in the peripheral blood, or “circulating tumor cells” (CTCs), provides an elegant solution to the study of tumor heterogeneity, because CTCs may be a more representative sample of invasive tumor cell populations derived from heterogeneous tumors in multiple sites within an individual by: As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are.

Alternatively, tumor heterogeneity might arise by clonal evolution, driven by mutations that confer growth advantage of a cell and its clonal progeny over other cells. Possibly, these models are not mutually exclusive: for instance, a driver mutation might have to occur in a cell with stem cell properties in order for it to elicit its driving Cited by: 6.

On the other hand, disruption of cell-cell contacts during the initial steps of cell culture establishment favors the outgrowth of specific cells, the composition of which do not recapitulate the original heterogeneity of a tumor.

Therefore, organotypic tumor slices without application of proteolysis would be the best model for drug selection Author: Aurimas Stulpinas, Aušra Imbrasaitė, Natalija Krestnikova, Audronė Valerija Kalvelytė. Find many great new & used options and get the best deals for Mammalian Tumor Cell Heterogeneity by Leigh at the best online prices at eBay.

Free shipping for many products. Tumor Cell Plasticity. Tumor cells are highly adaptive and known to undergo genetic, epigenetic, and phenotypic changes throughout tumorigenesis. This leads to intra-tumoral heterogeneity, which is a significant challenge for current cancer therapies.

Normal and neoplastic breast tissues are comprised of heterogeneous populations of epithelial cells exhibiting various degrees of maturation and differentiation.

While cultured cell lines have been derived from both normal and malignant tissues, it remains unclear to what extent they retain similar levels of differentiation and heterogeneity as that found within breast by: Tumor heterogeneity-an intriguing concept.

Cancer or malignant neoplasia is not any solo disease but a name for several more than related diseases all seen as a. The theories describing the establishment and maintenance of tumor heterogeneity are the cancer stem cell (CSC) hypothesis [] and the clonal evolution/selection model [], two concepts that were initially thought to be mutually exclusive, but are now perceived as potentially complementary [2, 16].Both concepts consider that tumors originate from single cells that have acquired multiple Cited by: Tumour Cell Heterogeneity and the Biology of Metastasis 1.

Hart 1 The metastatic spread of malignant tumours remains as one of the most intractable prob­ lems in clinical oncology. Experimental analysis of this phenomenon is fuelled by the hope that a more complete understanding of the process will give rise to insights allowing.

INTRODUCTION TO TUMOR HETEROGENEITY. The recognition of tumor heterogeneity and its clinical implications is not new. In fact, as early as the s, Foulds et al. [] suggested that cancer development was not a simple progression as in the single-cell theory; rather, cancers develop via complex, nonlinear advancements of genetic mutations that could vary over time, within single tumors, Author: Amanda K.

Seyer, Heather L. Lehman, David J. DeGraff. Spatial Heterogeneity Is a Fundamental Feature of the Tumor Microenvironment. It is important to recognize that the orchestrated influence of microenvironmental components on cancer is often accompanied by strong regional differences (Gillies et al.

; Junttila and de Sauvage ).Evidence of spatial variations has been well documented in pathological observations (Clemente et al. Cited by: Hyperdiploid tumor cells increase phenotypic heterogeneity within Glioblastoma tumors† Prudence Donovan,* a Kathleen Cato, b Roxane Legaie, c Rumal Jayalath, d Gemma Olsson, d Bruce Hall, d Sarah Olson, d Samuel Boros, e Brent A.

Reynolds f and Angus Harding * b. Tumor propagation models. In different tumor subtypes, cells within the tumor population exhibit functional heterogeneity and tumors are formed from cells with various proliferative and differentiation capacities. This functional heterogeneity among cancer cells has led to the creation of multiple propagation models to account for heterogeneity and differences in tumor-regenerative capacity.

A tumor can be considered as a highly heterogeneous functional tissue, connected and dependent on the microenvironment, which sends and receives signals to and from the tumor tissue itself.

Tumor cells alter the mechanical properties of the microenvironment in order to create favorable conditions for their proliferation. Stromal cells and non‐cellular elements of the extracellular matrix Cited by: 2.Tumor cell heterogeneity: origins and implications. New York: Academic Press. MLA Citation.

Coffey, Donald S. and Owens, Albert H. and Baylin, Stephen B. and Bristol-Myers Symposium on Cancer Research. Tumor cell heterogeneity: origins and implications / edited by Albert H.

Owens, Jr., Donald S. Coffey, Stephen B. Baylin Academic Press New.Given the variety of studies and data that have suggested the existence of heterogeneous populations or subpopulations of stem cells, this detailed volume examines different aspects of stem cell heterogeneity.

This goes against the long-held tenet that stem cells, defined by their capacity for.

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